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1994-10-25
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Document 2959
DOCN M94A2959
TI Carbohydrate malabsorption in patients with HIV infection.
DT 9412
AU Ginaldi L; Furia N; DiGiammartino D; Marani-Toto G; Corazza GR; Quaglino
D; Department of Int. Med., University of L'Aquila, Italy.
SO Int Conf AIDS. 1994 Aug 7-12;10(1):186 (abstract no. PB0173). Unique
Identifier : AIDSLINE ICA10/94369616
AB Patients with human immunodeficiency virus infection frequently have
intestinal dysfunction, such as abdominal pain, diarrhea and weight
loss, often associated with opportunistic infections or secondary
malignancies. We utilized breath hydrogen measurements to determine the
prevalence of carbohydrate malabsorption and its relationship with
intestinal symptoms and enteric pathogens at different stages of HIV
infection. 42 seropositive adult patients (29 males and 13 females, mean
age 29.9 years) and 44 healthy volunteers of comparable sex and age were
evaluated for disaccharide malabsorption using lactose hydrogen breath
test. Breath samples were collected from each subject studied
immediately before and every 30 minutes for 4 hours after the oral
ingestion of 20 gr. of lactose. Hydrogen concentration was measured
using a Quintron Model 12 microlyzer: an increase of more than 20 parts
per million was assumed as indicative of lactose malabsorption. A search
for intestinal pathogens including Salmonella, Shigella. Yersinia
enterocolitica, Campylobacter jejuni, Rotavirus, Parasites and their
ova, Candida albicans, Mycobacterium and Cryptosporidium was performed
accordingly to standard techniques. The prevalence of lactose
malabsorption was significantly higher (p 0.001; Chi square test) in HIV
infected patients (67.5%) compared with healthy controls (30%). We
therefore investigated the intestinal function in relation to the
progressive stages of HIV infection: the prevalence of lactose
malabsorption was significantly higher (p 0.001) in more advanced stages
of the disease (ARC and AIDS) compared with asymptomatic and LAS
patients (82.6% vs 47.3% respectively). Chronic diarrhea and/or weight
loss were present in 9 patients (5 AIDS and 4 ARC). Although all these
patients with intestinal symptoms presented lactose malabsorption,
microbiologic evaluation revealed intestinal pathogens only in 4 of
them. Intestinal dysfunction with carbohydrate malabsorption is a common
feature of HIV infection, even in the absence of clinically relevant
diarrhea or intestinal identifiable enteric infection; this may
contribute to the disease progression and malnutrition.
DE Adult AIDS-Related Opportunistic Infections/PHYSIOPATHOLOGY Breath
Tests Dietary Carbohydrates/*METABOLISM Disaccharides/METABOLISM
Female Human HIV Infections/*PHYSIOPATHOLOGY Intestinal
Absorption/*PHYSIOLOGY Lactose/METABOLISM Malabsorption
Syndromes/*PHYSIOPATHOLOGY Male MEETING ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).